The Los Angeles Rams will begin defense of their Super Bowl championship when they host the Buffalo Bills in the 2022 NFL Kickoff Game on Thursday, Sept. 8. The Rams made the fifth Super Bowl appearance in franchise history and second in four seasons last year and defeated Cincinnati 23-20 for their second title. Buffalo, which is the +600 favorite to win Super Bowl LVII, suffered a 42-36 overtime loss at Kansas City in the divisional round last postseason in one of the wildest playoff games in NFL history.
Kickoff from SoFi Stadium is set for 8:20 p.m. ET. Buffalo is a 2.5-point favorite in the latest Bills vs. Rams odds from Caesars Sportsbook, while the over/under for total points scored is 53. Before making any Rams vs. Bills picks, make sure to check out the expert NFL predictions and betting advice from SportsLine’s proven computer model.
The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn’t missed a top-rated pick since Week 15 last season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has simulated Bills vs. Rams in the NFL Kickoff Game 2022 10,000 times and just revealed its NFL expert picks and predictions. You can head to SportsLine now to see its picks. Here are several NFL odds and betting trends for Rams vs. Bills:
- Bills vs. Rams spread: Buffalo -2.5
- Bills vs. Rams over/under: 53 points
- Bills vs. Rams money line: Buffalo -135, Los Angeles +115
- BUF: Bills scored at least 31 points in 11 of their 19 games last season, including playoffs
- LAR: Rams have lost their last three home games against Buffalo
- Bills vs. Rams picks: See picks at SportsLine
Featured Game | Los Angeles Rams vs. Buffalo Bills
Why the Bills can cover
Scoring was rarely an issue for Buffalo last season, as the team was third in the league with an AFC-best 483 points and led the NFL with a plus-194 point differential. The Bills scored at least 26 points in 13 of their regular-season games and both playoff contests, including three of their seven overall losses. They won their second straight division title with an 11-6 record and posted all of those victories by 12 or more points.
Quarterback Josh Allen was the key to Buffalo’s offense, victimizing opponents with both his arm and his legs. The seventh overall pick in the 2018 NFL Draft, he became the first player in history to record more than 4,000 passing yards (4,407) and 750 rushing yards (763) in a season. The 26-year-old Allen threw for 36 scores and ran for six others, making him the only player with at least 100 touchdown passes (103) and 30 rushing TDs (31) over his first four NFL campaigns.
Why the Rams can cover
The Rams have performed exceptionally well in season-openers in recent years, going 19-3 in Week 1 since 2000 and 5-0 under coach Sean McVay. They also own the third-best overall record in the NFL since McVay took over in 2017 at 55-26. The Rams also will have history on their side, as Super Bowl champions are 14-3 in NFL Kickoff Games since 2004.
Los Angeles had one of the top aerial attacks in the league last season, ranking fifth in passing (273.1 yards) in Matthew Stafford’s first year with the club. The first overall draft pick in the 2009 NFL Draft, Stafford was third in the NFL with 4,881 yards and second with a career high-tying 41 touchdown passes. The 34-year-old’s arrival from Detroit resulted in a prolific campaign for Cooper Kupp, who posted the first 2,000-yard season by a receiver in league history with 1,947 in the regular season and 625 in the playoffs.
How to make Rams vs. Bills picks
SportsLine’s model is leaning Under on the total, projecting the teams to combine for 48 points. It also says one side of the spread has all the value. Head to SportsLine to see its NFL picks.
So who wins Bills vs. Rams in the NFL Kickoff Game 2022? And which side of the spread has all the value? Visit SportsLine now to see the Bills vs. Rams picks, all from the model that has returned over $7,500 on top-rated NFL picks, and find out.