Wednesday, February 8, 2023

Louisville vs. Syracuse prediction, odds, line: 2022 college football picks, Week 1 best bets from top model

The Louisville Cardinals and the Syracuse Orange will face off in an early season ACC clash at 8 p.m. ET on Saturday, September 3 at the Carrier Dome in Syracuse, N.Y. Both teams are looking to bounce back from mediocre 2021 season. The Orange lost their final three games of the season to finish 5-7, missing the postseason for the third consecutive year, while Louisville finished the 2021 campaign with a 6-7 overall record after losing to Air Force in the First Responder Bowl. Louisville has won three straight games against Syracuse and leads the all-time series 13-7. 

The Cardinals are favored by 4.5 points in the latest Syracuse vs. Louisville odds from Caesars Sportsbook, and the over-under is set at 56.5. Before locking in any Louisville vs. Syracuse picks, you need to see the college football predictions and betting advice from the proven computer simulation model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football side picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Syracuse vs. Louisville and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model’s picks. Here are several college football odds and betting lines for Syracuse vs. Louisville:

  • Syracuse vs. Louisville spread: Syracuse +4.5
  • Syracuse vs. Louisville over-under: 56 points
  • Syracuse vs. Louisville picks: See picks here.

Featured Game | Syracuse Orange vs. Louisville Cardinals

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Why Syracuse can cover

Syracuse has one of the most unique and decisive home field advantages in all of college football. The Carrier Dome is home to a raucous crowd and the Carrier Dome is simply unlike any other venue in the Football Bowl Subdivision. The Orange also happen to be 23-19 in home openers at the Carrier Dome.

Syracuse also returns one of the nation’s best running backs in Sean Tucker. The sophomore rushed for 1,496 yards and 12 touchdowns on 246 carries, while also catching 20 passes for 255 yards and 2 touchdowns in 2021.

Why Louisville can cover

Louisville quarterback Malik Cunningham is one of the most dynamic offensive players in the nation. The elusive senior from Montgomery, Ala. completed 62% of his passes for 2,941 yards and 19 touchdowns with 6 interceptions. He also rushed for 1,031 yards and 20 touchdowns, joining Lamar Jackson as the only other quarterback in school history to rush for over 1,000 yards in a season.

Cunningham absolutely shredded the Syracuse defense in 2021, throwing for 4 touchdowns and running another one in. The Cardinals won that game in blowout fashion 41-3.

How to make Syracuse vs. Louisville picks

The model has simulated Syracuse vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it’s also generated a point-spread pick that is hitting in well over 60% of simulations. You can only see the model’s pick at SportsLine.

So who wins Louisville vs. Syracuse? And which side of the spread hits in well over 60% of simulations? Visit SportsLine now to see which side of the Louisville vs. Syracuse spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out. 

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