The long-awaited return for pro football games that count finally ends on Thursday, September 8 when the Super Bowl champion Los Angeles Rams open the new season by hosting the Buffalo Bills in the 2022 NFL Kickoff Game. Kickoff is set for 8:20 p.m. ET from SoFi Stadium in Los Angeles. The last time a game was played at this venue, the Rams won the Super Bowl before their hometown fans in February, when they beat the Cincinnati Bengals 23-20. Their title defense comes with a home opener against the AFC East champion Bills, whose season ended in a memorable 42-36 overtime loss to the Kansas City Chiefs in the divisional round of the playoffs.
The Bills are 2.5-point favorites and the over-under for total points scored is 53 in the latest Bills vs. Rams odds from Caesars Sportsbook. Before locking any Rams vs. Bills picks, make sure you check out the NFL predictions and betting advice from SportsLine football analyst R.J. White.
White, a Fantasy and gambling editor for CBS Sports, consistently crushes as SportsLine’s No. 1 expert in NFL picks against the spread. He went 445-378-24 on his ATS picks from 2017-21, which returned $2,542 to $100 players. Moreover, he’s also 44-33 on NFL picks involving the Rams, lending critical insight into this matchup.
White is known for cashing out big in the Westgate Las Vegas SuperContest twice since 2015. He also cashed big on his NFL futures in 2021, including nailing Jonathan Taylor as the NFL rushing leader at 10-1. Anyone who has followed him has seen massive returns.
Now, White has studied the Bills vs. Rams Week 1 matchup from every angle and released a confident against-the-spread selection. You can head to SportsLine now to see White’s pick. Here are the NFL odds and betting lines for Bills vs. Rams:
- Bills vs. Rams point spread: Bills -2.5
- Bills vs. Rams over-under total: 53 points
- Bills vs. Rams money line: Bills -135, Rams +115
- BUF: Bills have covered four of the last five meetings in this rivalry
- LAR: Rams have covered five consecutive season-opening games
- Bills vs. Rams picks: See picks here
Featured Game | Los Angeles Rams vs. Buffalo Bills
Why the Bills can cover
Last year, the Bills were the only team in the NFL to rank in the top five in overall offense and defense. Many observers believe they will be improved on both sides of the ball, which is why they are favored to win the franchise’s first Super Bowl title this year. Last season, they finished 11-6 and won the AFC East before falling 42-36 in overtime to the Kansas City Chiefs in the divisional round of the playoffs.
Quarterback Josh Allen is an MVP frontrunner and is widely regarded to be the most versatile signal-caller in the game. Last year, he threw for 4,407 yards and 36 touchdowns while completing 63.3% of his passes. He also was the team’s second-leading rusher behind Devin Singletary (870 yards) with 763 yards and six scores. Additions such as versatile rookie running back James Cook have many observers predicting an even more lethal attack.
Why the Rams can cover
Coach Sean McVay recently told the media the team expects to have its top tandem of Cam Akers and Darrell Henderson at full health for the season-opener after both missed significant time last season. Akers, who is expected to be the lead running back, missed most of last year with a torn ACL, but returned ahead of schedule for the team’s postseason run. He logged 172 rushing yards and added eight catches for 76 yards.
Henderson was effective when healthy, but ended up missing the final five games of the season because of recurring soft-tissue injuries in the lower body. He still managed 149 carries for 688 yards and five touchdowns and added 176 receiving yards and three scores. After watching both running backs go through a series of full practices, McVay told the media he was excited about what he saw. “They look good. They got a few reps and that was a good thing. I expect all hands on deck,” McVay said.
How to make Rams vs. Bills picks
White has analyzed this matchup, and while we can tell you he’s leaning Over on the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. He’s only sharing what it is, and which side to back, at SportsLine.
So who wins Bills vs. Rams in the NFL Kickoff Game 2022? And which X-factor makes one side of the spread hit hard? Visit SportsLine now to see which side of the Bills vs. Rams spread you need to jump on, all from the expert who’s 44-33 on Rams picks, and find out.