The Cleveland Browns will try to win a Week 1 game for the first time since 2004 when they face the Carolina Panthers at Bank of America Stadium. Since beating the Ravens in the season-opener 18 years ago, the Browns are 0-16-1 in Week 1. In this year’s opener, they face former Cleveland quarterback Baker Mayfield, who’s now starting for the Panthers. Carolina is favored by two points in the latest NFL odds from Caesars Sportsbook, while the over/under for total points scored is 41.5. The game is one of 16 on a loaded Week 1 NFL schedule. Other key NFL matchups include the reigning Super Bowl champion Rams hosting the Bills in the 2022 NFL Kickoff Game and the Broncos‘ Russell Wilson returning to Seattle to face his former team, the Seahawks. Before you make any Week 1 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.
The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn’t missed a top-rated pick since Week 15 last season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has locked in five confident NFL best bets for Week 1. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 1 NFL picks at SportsLine.
Top Week 1 NFL picks
After simulating every game 10,000 times, the model is high on the Indianapolis Colts to cover as eight-point road favorites against the Houston Texans. Houston had the worst offense in the NFL last season, averaging 278.1 yards a game. The offense also ranked last in the league in rushing offense (83.6 yards a game).
That offense faces an Indianapolis defense that thrived on forcing turnovers last season. The Colts had 33 takeaways last year, second most in the NFL behind only the Cowboys (34). In two games against the Texans last year, Indianapolis forced a combined five turnovers while committing only one. See which other NFL parlay picks to make here.
How to make Week 1 NFL parlays
The model also jumped on four other NFL matchups where it says the line is way off, including an underdog that wins outright. You can only see the model’s NFL Week 1 best bets and parlay at SportsLine.
What are the model’s top Week 1 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 1 NFL best bets from a model on a 138-97 run on its top-rated picks, and find out.