The No. 25 BYU Cougars have won 13 of their last 15 season openers, and they will be looking for another Week 1 victory when they go on the road to face South Florida on Saturday afternoon. BYU has won five of its six openers under head coach Kalani Sitake, with the lone loss coming against Utah in 2019. South Florida has only picked up one win against FBS opponents over the last two seasons, but it has 18 starters returning from last year.
Kickoff is set for 4 p.m. ET. The Cougars are favored by 11.5-points in the latest South Florida vs. BYU odds from Caesars Sportsbook, while the over/under is set at 58. Before entering any BYU vs. South Florida picks, you’ll want to see the college football predictions from the advanced computer model at SportsLine.
The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football side picks that dates back to 2021. Anyone who has followed it has seen huge returns.
- South Florida vs. BYU spread: South Florida +11.5
- South Florida vs. BYU over/under: 58 points
- South Florida vs. BYU money line: BYU -430, South Florida +328
Featured Game | South Florida Bulls vs. BYU Cougars
Why BYU can cover
BYU has excelled in season openers under Sitake, winning five of his six Week 1 games. The Cougars return fifth-year junior quarterback Jaren Hall, who made his first career start against South Florida in 2019. Hall went over 300 yards on four occasions last season, but he missed the game against USF due to a rib injury.
He finished the 2021 campaign with 2,583 passing yards and 20 touchdowns, and he is facing a South Florida team that only has one win over an FBS opponent during the last two seasons. BYU dominated Central Florida in a 49-23 final in the 2020 Boca Raton Bowl, so the Cougars are comfortable playing in the humidity. South Florida has failed to cover the spread in five straight season openers and ended last season on a five-game losing streak.
Why South Florida can cover
South Florida might have just one win over FBS teams since 2020, but the Bulls are poised to take a huge step forward this year. They are returning 18 starters from last year’s team and added multiple key transfers during the offseason. Baylor transfer Gerry Bohanon won the starting job during fall camp, giving South Florida an experienced signal caller.
The Bulls also have their top wide receiver and top running back on the field again this season, so the combination of returning production and transfer portal talent will make this a completely different unit than last year. They were able to play a competitive game with BYU in 2021, so South Florida will be confident in its ability to pull off an upset on Saturday afternoon. The Bulls covered the spread in five of their last seven games last season, while BYU only covered twice in its final eight games.
How to make South Florida vs. BYU picks
The model has simulated South Florida vs. BYU 10,000 times and the results are in. We can tell you that the model is leaning Over, and it’s also generated a point-spread pick that is hitting in well over 70% of simulations. You can only see the pick at SportsLine.
So who wins BYU vs. South Florida? And which side of the spread hits in well over 70% of simulations? Visit SportsLine now to find out which side of the South Florida vs. BYU spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.