The new NFL season begins on Thursday, September 8 with Rams vs. Bills in the 2022 NFL Kickoff Game. The return of professional football also means fans are entering their NFL office pool picks. Whether you’re choosing games straight-up or against the spread, making your Week 1 NFL picks can be challenge. It was a busy offseason and the Week 1 NFL schedule is loaded with eight games with NFL spreads of 3.5 points or fewer. Cowboys vs. Buccaneers on Sunday Night Football and Panthers vs. Browns on Sunday have the two smallest NFL lines of the week, with Tampa Bay and Cleveland favored by 1.5. Which teams should you back with your Week 1 NFL confidence pool picks? Before you make your NFL predictions, you need to see the Week 1 NFL football pool picks from SportsLine’s proven model.
The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season.
More importantly for NFL confidence pool players, the model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports office pool players four times during that span. Anyone who has followed it is way up.
Now, the model has simulated the entire Week 1 NFL schedule 10,000 times and generated its optimal NFL pick’em plays. Go to SportsLine to see them now.
Top Week 1 NFL office pool predictions
One of the top Week 1 NFL predictions from the model: The Eagles cruise past the Lions on the road for a comfortable five-point victory, covering the spread. After going 4-11-1 in 2020 and firing Super Bowl-winning head coach Doug Pederson, Nick Sirianni managed to carry the Eagles to a 9-8 record and a playoff berth last season.
Jalen Hurts had an up-and-down season leading the Eagles’ offense, but his ability to impact the game as a runner and passer gave the front office to make significant investments to surround him with talent. The Eagles made a blockbuster draft-day trade to acquire former Titans wide receiver A.J. Brown, and the combination of Brown and Devonta Smith gives the Eagles one of the most exciting tandems in the NFL.
The Lions are coming off a 3-13-1 season and ranked last in the NFL in net yards allowed per pass attempt (7.2). The model expect Smith and Brown to combine for over 140 yards receiving and for Hurts to pile up nearly 300 yards of total offense and two touchdowns. That helps Philadelphia win in well over 60 percent of simulations. See the rest of the model’s Week 1 NFL pool picks here.
How to make Week 1 NFL office pool picks
The model also made the call on every other Week 1 NFL game and has strong picks for potentially close matchups like Cowboys vs. Buccaneers and Vikings vs. Packers. It’s also calling for one underdog to pull off an upset and several Super Bowl contenders to go down hard. You can only see all of the model’s NFL pool picks here.
So who should you pick in every Week 1 NFL game? And which Super Bowl contenders go down? Visit SportsLine now to get optimal NFL office pool picks, all from the advanced computer model that has ranked in the top 10 on straight-up picks four of the last six years and went an outstanding 138-97 on top-ranked picks against the spread since 2017.